For instance, SIPL1 (Shank-Interacting Protein-Like 1) has reported to have overexpression during breast cancer tumorigenesis, and inhibiting the expression of SIPL1 may contribute to inhibition of breast cancer [7]. PLA2G16 has been proved as an important prognostic factor in primary osteosarcoma patients [8]. Dicerl has been found to be expressed at low level in nasopharyngeal carcinoma tissues no matter whether at the gene or at the protein levels, and it could also be a novel prognostic biomarker [9]. Here, SHARPIN is linked to osteosarcoma.