Kivirikko et al. showed that TNF-α can inhibit the expression of P4H, which promotes the formation of collagen that makes the atherosclerotic plaques vulnerable [33, 34], and it can inhibit the endothelial cells' function, induce lipid deposition, and promote the generation of inflammatory cytokines to aggravate atherosclerosis [25, 35]. The gene discussed is TNF; the disease is atherosclerosis.