The PI3K/Akt pathway is known to promote GLUT4 expression in myocytes and adipocytes (Bryant et al., 2002), and the activation of Akt may be an essential requirement for ameliorating IR, a typical characteristic of NAFLD/NASH (Vidyashankar et al., 2013; Hojlund, 2014). This evidence concerns the gene AKT1 and metabolic dysfunction-associated steatotic liver disease.