PPARGC1A and amyotrophic lateral sclerosis: These changes might be resulted from the perturbation of the link between PPARγ-regulated lipid metabolism and mitochondrial oxidative phosphorylation (Capitanio et al., 2012), suggesting that effective ALS intervention may be required to coordinate lipid oxidation with the increase of mitochondrial number (PGC-1α) and the improvement of the integrity and efficiency of mitochondria (Liu et al., 2011).