DYRK1A and Dravet syndrome: These defects have been reproduced in a number of different mouse models of DS (Ts1Rhr, Ts65Dn, Ts1Cje, Dp(16)1Yey) as well as mice with altered copy numbers of Dyrk1a (hBACtgDyrk1a, hYACtgDyrk1a, mBACtgDyrk1a, Dyrk1a+/−).