EGF and neoplasm: Cancer pain can be caused by different mediators: immune system cells infiltrating the tumor: neutrophils, T cells, and macrophages secrete prostaglandins, endothelin, TNF-α, Transforming Growth Factor (TGF), IL-1 and IL-6, Epidermal Growth Factor (EGF), and Platelet Derived Growth Factor (PDGF) [1, 9].