JAK1 and Splenomegaly: Although patients are exposed to an increased risk of infections during treatment with JAK1/2 inhibitors, this novel treatment modality has definitely demonstrated its efficacy in terms of improvement of quality of life due to a rapid resolution of constitutional symptoms within days in concert with a marked reduction in symptomatic splenomegaly within the next weeks or months in the large majority of patients with myelofibrosis [77–80].