LEP and obesity due to melanocortin 4 receptor deficiency: One hallmark of obesity is a systemic low-grade inflammation with increased levels of many inflammatory markers such as C-reactive protein (CRP), interleukin- (IL-) 6, tumor necrosis factor- (TNF-) α, and leptin, and this is maybe important for the pathogenesis of obesity-related asthma [34, 42–45].