In addition to markers of eosinophilic inflammation, these patients showed high systemic total IgE (>450 kU/L) [161]. Staphylococcus aureus enterotoxin-driven massive IgE production and Th2 inflammation may be one mechanism explaining the overlap between severe asthma, rhinitis, and/or nasal polyps [157, 159, 161]. The gene discussed is IGHE; the disease is asthma.