Seropositive patients with nonatopic adult-onset asthma used high doses of inhaled and/or oral steroids suggesting that they were relatively insensitive to steroids and may require alternative treatment options [7]. C. pneumoniae could function by activating C. pneumoniae-specific IgE/FcεR1 complex on mast cells or basophils, enhancing Th2 inflammatory response [164]. Here, IGHE is linked to asthma.