PTGES and hepatocellular carcinoma: Apparently, our study reveals that caffeine could effectively reduce PGE2 synthesis in HBx(+) hepatocytes by specifically blocking the PPARγ-EGR1-mPGES-1 pathway and delay the effect of PGE2 in promoting HCC growth, which provides a new evidence of molecular biology for the hypothesis that drinking coffee is beneficial to HBV-infected patients.