For example, HRP, HP, APOA1, ALDOB, ITIH4, ORM1, SERPINA1, HRG, and MT2A are mRNAs that express differentially between tumors (HCC and ICC) and non-tumors (ICC-NT and HCC-NT), while ALB, APOE, RBP4, TTR, AMBP, APOA2, APOC3, APOH, CES1 and APOC1 are expressed in ICC distinctly from the other three samples. The gene discussed is APOE; the disease is intrahepatic cholangiocarcinoma.