INS and intrahepatic cholangiocarcinoma: RNA synthesis related pathway (RNA transport, Ribosome biogenesis in eukaryotes, Ribosome, RNA polymerase, Aminoacyl-tRNA biosynthesis) and glucose-lipid synthesis pathway (Adipocytokine signaling pathway, Insulin signaling pathway) were found to be associated with ICC carcinogenesis (Supplementary Table 7).