For example, HRP, HP, APOA1, ALDOB, ITIH4, ORM1, SERPINA1, HRG, and MT2A are mRNAs that express differentially between tumors (HCC and ICC) and non-tumors (ICC-NT and HCC-NT), while ALB, APOE, RBP4, TTR, AMBP, APOA2, APOC3, APOH, CES1 and APOC1 are expressed in ICC distinctly from the other three samples. This evidence concerns the gene APOE and hepatocellular carcinoma.