When analysing vascular Klotho expression levels according to the presence of cardiovascular disease and cardiovascular risk factors, we observed that individuals with coronary artery disease had a significantly lower expression of Klotho: Log a.u. in coronary artery disease patients, 0.30 ± 0.12 versus non‐coronary artery disease patients, 0.78 ± 0.18 (P < 0.05; Table 2). Here, KL is linked to coronary artery disorder.