Because immune suppressive factors (e.g. IL-10, TGF-b) in tumor microenvironment would induce Treg, T cell exhaustion or anergy, it is plausible that the combination of HER-3 peptide and Th1-polerized adjuvants such as heat shock protein 70 fragment33 are required to completely suppress Treg induction and obtain high-functionalized Th1 in vivo. This evidence concerns the gene ERBB3 and neoplasm.