Although it is difficult to simply consider lymphocyte infiltration as a surrogate marker for the immunogenicity of HER-3 because tumor is known to inhibit lymphocyte infiltration by soluble factors (e.g. semaphorin 4D) in most likely TCR-independent manner22, we found in the TCGA database that 66% of the HNSCC samples, which have an amplified expression of HER-3 gene, have lymphocyte infiltration23. This evidence concerns the gene SEMA4D and neoplasm.