Although IFN-γ production from CD4 T cell may not show a direct antitumor effect, it is still possible that this cytokine can be a prognostic marker in vivo because IFN-γ production in tumor microenvironment could upregulate antitumor immunity in an indirect manner by augmenting CD8 T cell reactivity to tumor cells subsequent to MHC class I expression. This evidence concerns the gene CD4 and neoplasm.