After morusin treatment, transcription factors C/EBP β and PPARγ, adipogenic proteins including adipsin D and perilipin were increased significantly (p < 0.05, Fig. 7) both in morusin treated cancer cells and tumor tissues, which were widely used molecular markers of adipocyte differentiation [36–39]; In apoptotic protein expression, anti-apoptosis protein, Bcl-2 were decreased, pro-apoptosis protein, bax and active caspaes-3 were increased significantly (p < 0.05, Fig. 8), which play important roles in the regulation of mitochondrial-mediated apoptosis [40, 41]. This evidence concerns the gene BCL2 and cancer.