In accordance with previous reports, with two major bands being present at 60 and 64 kDa in PiD, two major bands at 64 and 68 kDa in PSP, CBD and MAPT, and three bands at 60, 64 and 68 kDa in AD were detected, confirming that the band patterns of hyperphosphorylated full-length tau are useful for biochemical diagnosis of 3R and 4R tauopathies. This evidence concerns the gene MAPT and tauopathy.