Our study confirms that five of these SNPs (rs7574865 in STAT4, rs9267673 near C2, rs2647073 and rs3997872 near HLA-DRB1 and rs9275319 near HLA-DQ) also affect individual susceptibility to HBV-related LC. This evidence concerns the gene HLA-DRB1 and laryngotracheoesophageal cleft.