In the present study, we examined the association of fifteen SNPs derived from seven GWASs on susceptibility of HBV- or HCV-related HCC with the risk of HBV-related LC in the Chinese population, and found that rs7574865 in STAT4, rs9267673 near C2, rs2647073 and rs3997872 near HLA-DRB1 and rs9275319 near HLA-DQ, were significantly associated with the risk of HBV-related LC. The gene discussed is HLA-DRB1; the disease is laryngotracheoesophageal cleft.