HLA-DQA2 and hepatocellular carcinoma: Nevertheless, it’s worth noting that one SNP near HLA-DQA2 (rs9275572) showing a significant association (P = 0.02, OR = 0.84, 95% CI = 1.32–2.62) with the risk of HBV-related HCC (Supplementary Table S1) exhibited an opposite direction of effect in the progression from CHB to LC (P = 0.6, OR = 1.04, 95% CI = 0.90-1.20) (Table 4).