Such an observation is in keeping with previous studies showing reduced anxiety-like behaviour in unconditioned tests of anxiety13, 14, 33, 34 and reduced ACTH response to mild and severe stressors following treadmill exercise17, but is in disagreement with another study showing lack of treadmill effects on fear conditioning or escape-learning deficit produced by uncontrollable stress35. The gene discussed is POMC; the disease is Anxiety.