2010). In the RVLM of experimental models of CHF, there is reduced expression of the voltage-gated K+ channel protein (Kv)4.3, that has been demonstrated in the RVLM of experimental models of CHF (Gao et al. 2010). This protein contributes to the generation of IA (Sonner and Stern 2007; Carrasquillo et al. 2012). In agreement with these findings, in vitro studies have demonstrated reduced IA amplitude and Kv4.3 expression following 6-h treatment of catecholaminergic CATH.a cells with Ang II (Gao et al. 2010). Here, AGT is linked to congestive heart failure.