As a further support for the role of BCL-xL in a wide range of B lymphoid malignancies, the clinical outcome of GCB-DLBCL patients is better than of those with non-germinal center-DLBCL, likely also due to the fact that GCB-DLBCL cells have significantly lower BCL-xL expression [29, 52]. This evidence concerns the gene BCL2L1 and diffuse large B-cell lymphoma.