Regardless of the different nature of the genes H19 controls by this mechanism (for example: the cancer related Igf2 on one hand and cell cycle inhibitor Cdkn1c and Igf2r growth repressor on the other), the model used to show H19 control over the IGN was based on H19 KO (knockout) mice manifesting an overgrowth phenotype and subsequent mating of H19 transgenic with the KO mice to rescue the phenotype [88]. This evidence concerns the gene H19 and cancer.