TNK2 and neoplasm: However, compared with HCCLM3shcontrol group, knockdown of Ack1 in HCCLM3 cells significantly decreased tumor growth (P = 0.004; Figure 4Ab), intrahepatic metastasis nodules (P < 0.001; Figure 4Bb), pulmonary metastasis rate (2/7(28.6%) vs 7/7(100.0%), P = 0.026; Figure 4Da & 4Db & 4Dc), pulmonary metastatic nodules (6 ± 1.3 vs. 29 ± 3.2, respectively, P < 0.001; Figure 4Da & 4Db & 4Dd).