These results strongly support the concept that ACSL4 acts on the two components of mTOR, the rapamycin and nutrient-sensitive multiprotein complex and also the nutrient-insensitive mTOR-containing complex, and may help explain the strong capacity of the sole transfection of ACSL4 to change the phenotype of breast cancer cells as previously described [4]. The gene discussed is MTOR; the disease is breast cancer.