CXCL8 and CAPN5-related vitreoretinopathy: Given the proinflammatory and proproliferative effect of Chlamydia trachomatis on RPE cells, which was demonstrated by the upregulation of collagen type IV, collagen type I, IL-8, TGF and FGF, the results of the study should be extrapolated primarily to humans with proliferative vitreoretinopathy, because in this disease, production of ECM (including collagen type I) [29], TGF [30, 31], FGF [31], and IL-8 [32] is of particular importance.