Pharmacological antagonism with selective inhibitors of either EGFR phosphorylation by AG1478 or ErbB2 receptor phosphorylation by AG825 corrected the vascular dysfunction associated with diabetes as evidenced by a normalization of the hyper-responsiveness of blood vessels to vasoactive agents such as Ang II and Norephinephrine (NE) [4,7,8,20]. Here, EGFR is linked to diabetes mellitus.