ANGPT1 and diabetes mellitus: Diabetes-induced phosphorylation of ErbB2 receptor was significantly attenuated by chronic treatment with Ang (1–7) or AG825, a selective inhibitor of ErbB2 receptor, at multiple tyrosine residues Y1221/1222, Y1248 (detected by two separate antibodies and labeled as Y1248a or Y1248b) and Y877 in the mesenteric vascular bed of STZ-induced diabetic rats (Fig 1 panels i-vii).