Further, chronic Ang-(1–7) or AG825 treatment opposed the diabetes-induced reduction in total or phosphorylated (Ser1177) eNOS, elevation in phosphorylated IkB-α (a commonly used marker for NF-kB activity) and reduction in total eNOS in the mesenteric vascular bed (Fig 2b). The gene discussed is NFKB1; the disease is diabetes mellitus.