NFE2L2 and cancer: Since understanding Nrf2 regulation, and identifying Nrf2 activators or inhibitors that may play a role in disease prevention or cancer cell sensitization during therapy, would have a significant impact on cancer therapy, we studied these constructs in MDA-MB231 triple negative breast cancer cells stably expressing Nrf2-FLuc2 fusion in response to an array of Nrf2 activators and measured for the luciferase activity.