We constructed luciferase fusion with N-terminal Nrf2 fragments of different amino acid lengths (50, 100, 150, 200, 250, 350, and 435 aa) and examined the efficiency of luciferase activation in response to Nrf2 activators in the presence and absence of anticancer drugs in MDA-MB231 triple negative breast cancer cells. The gene discussed is NFE2L2; the disease is triple-negative breast carcinoma.