As the ultimate aim of this study is to evaluate the antioxidant mediated Nrf2 activation and chemosensitization in cancer therapy, first, we tested the apoptotic effects of two selective antioxidants applied alone at different concentrations and for various time points in MDA-MB231 triple negative human breast cancer cells, and 4T1 murine mammary adenocarcinoma cells. This evidence concerns the gene NFE2L2 and breast cancer.