INTS8 and cancer: Mutations in CACNA2D (a voltage-dependent calcium channel), INTS8 (a component of small nuclear RNA transcription complex), KCNH8 (a potassium voltage-gated channel), NTRK3 (tyrosine-protein kinase receptor), TP53 (p53), and TRMT12 (a guanosine modifying transferase) were identified in 2 samples and predicted to be cancer driver mutations impacting protein function by all 4 algorithms (Fig 3A).