Furthermore, the three PTCL samples (two T-PLL, one HSTL) with mutations in γc signal transduction components in our study were among the samples containing mutations in ATM. Our study suggests that, due to overlap of mutations in ATM and the γc signaling pathway, there is a possible correlation between these two pathways in HSTL as well as T-PLL. The gene discussed is ATM; the disease is mature T-cell and NK-cell non-Hodgkin lymphoma.