PLCG1 and adult acute megakaryoblastic leukemia: For example, M-β-CyD treatment decreases Akt phosphorylation in a time-dependent manner in human epidermoid carcinoma cells [10], whereas M-β-CyD has no effect on the phosphorylation of Akt, PLCγ1, and ERK1/2 in human megakaryoblastic leukemia cells [71].