Consistent with our findings in mouse melanoma cells, DMPB (30 μM) treatment of human melanocytes triggered increases in melanin synthesis (Fig 5A), tyrosinase expression (Fig 5B, top panel), total tyrosinase activity, (Fig 5B, bottom panel), and intracellular tyrosinase activity together with increased dendrite formation (Fig 5C), whereas DMPB (30 μM) did not affect on the proliferation of human melanocytes (Fig 5D). Here, TYR is linked to melanoma.