Many genes have been implicated in the development of microcephaly (summarized inTable 1) includingASPM,MCPH1,CDK5RAP2,CEP152,CENPJ,WDR62,STIL,CASC5,CEP135,ZNF335,PHC1,CDK6, with many of them contributing to centrosome and spindle protein dysfunction during mitosis6,10,13–17. Here, CDK5RAP2 is linked to microcephaly.