hMLH1 is frequently methylated in endometrial cancer tissues and may induce mutation of cancer-associated genes including human mutS homolog 6 (hMSH6), type II transforming growth factor-beta (TGF-βII), Bcl2-associated X protein (BAX) and PTEN (Banno et al., 2012[2]). The gene discussed is BAX; the disease is endometrial cancer.