Paradoxically, low IGF‐1 levels are associated with increased risk for numerous diseases of aging in humans, including cardiovascular disease (CVD) (Juul et al., 2002), type 2 diabetes (T2DM) (Sandhu et al., 2002), and frailty (Leng et al., 2004). This evidence concerns the gene IGF1 and type 2 diabetes mellitus.