Furthermore, asparaginase resistance leading to subsequent relapse in patients with ALL has been mainly attributed to the increased expression of AS and to the reduced efflux of asparagine in leukaemia cells21, 24 that are mediated by various signalling events involving amino acid response, survival-related MEK/ERK and mTORC pathways21, 50. The gene discussed is MAP2K7; the disease is acute lymphoblastic leukemia.