The cholinergic concept of Alzheimer’s disease (AD) was initially resulted from postmortem studies of the brain [1, 2], which ultimately led to the development of new drugs based on the inhibition of the key enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) [3, 4]. This evidence concerns the gene ACHE and early-onset autosomal dominant Alzheimer disease.