TNF and melanoma: This approach clearly illustrates how the MITFlow/c-JUNhigh switch coincides with the acquisition of a dedifferentiated phenotype in human melanomas as reflected by the loss of melanocytic gene expression (MLANA) and the high levels of AXL, NGFR and EGFR. Furthermore, MITFlow/c-JUNhigh melanomas have an increased activity of the TNF response gene set and hence pro-inflammatory pathway activity in line with our results shown so far.