Melanoma samples were sorted by increasing MITF levels and we plotted for each sample the respective expression of c-JUN, FOSL1, the TNF-α response signature MLANA and the dedifferentiation makers AXL, NGFR and EGFR (Fig. 6a–d and Supplementary Fig. 7a–c)6, 21, 24, 44. The gene discussed is JUN; the disease is melanoma.