The band of cleaved caspase-3 was not detected in Lats1+/+ and Lats1−/− MEFs (top panel, lanes 3 and 4), whereas human cervical cancer cells, HeLa-S3, exhibited the increase of cleaved caspase-3 by UV irradiation (top panel, lane 2). The gene discussed is CASP3; the disease is cervical carcinoma.