Therefore, centrosomal Lats1 seems to coordinately regulate precise progression of DNA replication and centrosome during S phase, which might explain its role in disorders associated with body growth failure, such as dwarfism, although cytoplasmic or nuclear Lats kinases are known to suppress overgrowth of certain organs (e.g., liver) by inhibiting Yap and Taz in the Hippo pathway. The gene discussed is LATS1; the disease is Severe short stature.