Some studies indicated a positive correlation between GRP78 and tumor malignancy (epithelial ovarian tumors7, diffuse large B cell lymphoma8, renal cell carcinoma9, endometrial carcinoma10, gastric carcinoma11, and prostate cancer12), while some other studies came to an opposite conclusion (colorectal carcinoma13, oral squamous cell carcinoma14, and esophageal adenocarcinoma15). Here, HSPA5 is linked to neoplasm.