OBSCN and hypertrophic cardiomyopathy: Deletion of OBSCN in a zebrafish model resulted in defects in skeletal muscle, as well as in cardiac and neural development (Perry et al. 2013), whereas in disease, the p.R4344Q variant (not identified in this study) of OBSCN has been associated with hypertrophic cardiomyopathy, and other variants have been associated with various cancers (Perry et al. 2013).