Carcinomas from eligible patients for treatment with TZB must present HER2-positive status, attested by protein overexpression (score 3+) by immunohistochemistry (IHC) or gene amplification by in situ hybridization (ISH) for tumors with equivocal IHC results (score 2+) [11, 12]. Here, ERBB2 is linked to carcinoma.