AQP4 and neuromyelitis optica: These findings recapitulate observations which have been made earlier in an EAE model using myelin basic protein-specific T cells with demyelinating anti-MOG antibodies [17], and suggest that the large, astrocyte-destructive lesions in NMO-IgG seropositive NMO patients could be provoked by the action of very few AQP4-specific T cells.