CFLAR and neoplasm: Given the number of literature reports of calmodulin antagonists sensitizing Fas-mediated apoptosis in a number of tumor cells, as well as the growing number of reports demonstrating direct interactions between calmodulin and almost each individual DISC component (Fas, FADD, cFLIP), it is plausible to envision calmodulin playing a role in DISC formation and function [8, 20–24, 26, 45, 48, 49].