ITGAE and Cowden disease: Total IELs (CD103+CD45+), non-T cells (CD103+CD45+CD3−), TCRγδ+ cells (CD103+CD45+CD3+TCRγδ+) and TCRαβ+ cells (CD103+CD45+CD3+TCRγδ−) were studied within the intraepithelial compartment (as characterized in Figure 1A) given their relevance as biomarkers in CD diagnosis [9,32].