Caspase-independent chondrocyte death was further defined in peroxynitrite-induced death, which involved calcium-dependent cysteine proteases (calpains), and in chondrocyte necroptosis induced by the retention of D469del-COMP, a mutated cartilage oligomeric matrix protein gene (COMP) implicated in pseudoachondroplasia [66,131]. Here, COMP is linked to pseudoachondroplasia.