From these sarcomas, we tested 2 samples expressing high levels of CDK4 and cyclin D1 (S11 and S16), 2 samples expressing high p16ink4a levels (S23 and S27), and two samples expressing normal levels of CDK4, low levels of cyclin D1 and no detectable p16ink4a (S14 and S29) (Figure 4C). This evidence concerns the gene CDK4 and sarcoma.