CDKN2A and sarcoma: From these sarcomas, we tested 2 samples expressing high levels of CDK4 and cyclin D1 (S11 and S16), 2 samples expressing high p16ink4a levels (S23 and S27), and two samples expressing normal levels of CDK4, low levels of cyclin D1 and no detectable p16ink4a (S14 and S29) (Figure 4C).