HIF1A and neoplasm: Concomitantly, upon ERK inactivation, the decreased level of HIF-1α in the miR-622-overexpressing A549 cells was restored upon transfection with either of two shFOXO3a constructs (Figure 6D), which also resulted in enhanced tumor cell invasiveness compared with control oligonucleotide-transfected cells (Figure 6E).