HIF1A and hereditary clear cell renal cell carcinoma: For example, deficiency of von Hippel-Lindau function counters the degradation of HIF-1α under normoxia [16, 36], and HIF-1α represses the transcription of the E-cadherin gene, contributing to EMT in von Hippel-Lindau-null renal cell carcinomas [16, 37].