Moreover, this decrease in invasiveness of A549 cells transfected with shERK1/2 was restored upon transfection with shFOXO3a, again confirming the role of the FOXO3a-miR-622 axis in repressing HIF-1α expression to account for ERK activation and its consequent upregulation of the invasiveness of human lung cancer cells (Figure 7E and 7F). This evidence concerns the gene HIF1A and lung cancer.