HIF1A and lung carcinoma: Moreover, this decrease in invasiveness of A549 cells transfected with shERK1/2 was restored upon transfection with shFOXO3a, again confirming the role of the FOXO3a-miR-622 axis in repressing HIF-1α expression to account for ERK activation and its consequent upregulation of the invasiveness of human lung cancer cells (Figure 7E and 7F).