Interestingly, in both Apcfl/flPtenfl/fl mice and Apcfl/flPtenfl/flCtnnb1fl/+ mice, adenocarcinomas morphologically similar to human OEAs formed following AdCre injection, with 100% penetrance and no difference in tumor latency between mice with two wild type Ctnnb1 alleles or one wild type and one floxed Ctnnb1 allele (Table 1). This evidence concerns the gene CTNNB1 and adenocarcinoma.