In addition, no significant differences in survival rates, tumor volumes, and rates of liver metastasis were found between AdCre-injected Apcfl/flPtenfl/fl mice and Apcfl/flPtenfl/flCtnnb1fl/+ littermates (Table 1), and OEAs arising in both lines of mice shared similar histological features and immunohistochemical staining patterns for cytokeratin-8 (CK8), E-cadherin and α-inhibin (Fig 8A and Table 1). This evidence concerns the gene KRT8 and neoplasm.