APC and cancer: In addition, our OEA model work contrasts with the prior published work, as it also relies on somatic targeting of Apc and Ctnnb1. The OEA results also differ from our own colon tumorigenesis results, as the findings indicate Ctnnb1 hemizygous gene dosage had no demonstrable effect on cancer latency, size, or morphology or the metastatic potential of mouse OEAs arising from combined somatic inactivation of Apc and Pten.