CTNNB1 and neoplasm: Interestingly, in both Apcfl/flPtenfl/fl mice and Apcfl/flPtenfl/flCtnnb1fl/+ mice, adenocarcinomas morphologically similar to human OEAs formed following AdCre injection, with 100% penetrance and no difference in tumor latency between mice with two wild type Ctnnb1 alleles or one wild type and one floxed Ctnnb1 allele (Table 1).