The anti-PDPN antibodies NZ-1 that are either radiolabeled with N-succinimidyl 4-guanidinomethyl 3-[131I]iodobenzoate or fused to Pseudomonas exotoxin A carrying a C-terminal KDEL peptide exhibited significant suppression in the tumor growth of malignant glioma [51, 52]. This evidence concerns the gene PDPN and malignant glioma.