As the STAT3 phosphorylation at Ser(727) is triggered by active RSK2 or JNK1 in the presence of intracellular phosphorylation process of ATM [56], the exact crosstalk between ATM and other NF-κB upstream molecules in IL-6 correlated lung cancer metastasis still need further exploration. The gene discussed is STAT3; the disease is lung carcinoma.