IL6 and lung carcinoma: As the MMP family is comprised of more than 25 related zinc-dependent enzymes [34], the findings that MMP-3/MMP-13 is involved in ATM activation increasing cell migration (Figures 2–6) and IL-6 increases MMP-1/MMP-2 expression (Supplementary Figure S2) cannot exclude the possibility that other MMPs might also contribute to inflammation-associated lung cancer metastasis.