The three main focuses to elucidate in our study were as follows: (1) the molecular associations between EPCAM loss, germline deletion and promoter methylation of the EPCAM gene, and the MSI/CIMP statuses in CRC, (2) the histopathologic correlations of EPCAM loss in CRC, and (3) the prognostic significance of EPCAM loss in CRC. This evidence concerns the gene EPCAM and colorectal carcinoma.