There are tumours in CRC patients (TCGA data from http://cbioportal.org, [31]) that can have an akt2 gene amplification or a homozygous deletion or missense mutation of akt1. AKT2 induces migration while AKT1 inhibits migration thus the ratio AKT1 to AKT2 might be an important determinant for acquiring metastasis in the colon. The gene discussed is AKT1; the disease is neoplasm.