Since single gene-based analysis of colon cancer did not show significant differential changes in the expression of the influence network genes, we investigated the expression of the downstream targets for the transcription factors in the modular network (Notch_pthw, p53, p63_p73, EMT regulators, etc.)and recapitulated their expression into a pathway activity score (see Methods). This evidence concerns the gene TP53 and malignant colon neoplasm.