TGFB1 and neoplasm: The triple mutant: Notch_pthw GoF, p53 LoF and TGFb_pthw LoF leads to one stable state in which the EMT_reg is ON but no metastasis, migration, invasion or apoptosis are reachable (S2 Table) indicating that activation of TGF-β pathway (e.g., by the peripheral tumour cells more exposed to the micro-environment) is required to have metastasis in the double mutant by activating invasion [118,119].