Tumor status induced a significant increase in the expression of CerS2 (p < 0.0001), CerS6 (p < 0.0001), DEGS2 (p < 0.0001), SMPD1 (p < 0.05), and CLN3 (p < 0.0001); and a significant decrease in the expression of UGT8 (p < 0.0001) compared with expression in the corresponding non-tumor tissue (Figure 3B). The gene discussed is SMPD1; the disease is neoplasm.