Targeting of collagen and hyaluronic acid using angiotensin receptor blockers (ARBs) or angiotensin-converting enzyme (ACE) inhibitors, which are widely used as anti-hypertensive drugs, was found to improve delivery of chemotherapeutic agents and nanomedicines in pancreatic and breast tumors via stress alleviation by decreasing stromal expression of TGFβ as well as other fibrosis-inducing signaling molecules (107, 108). The gene discussed is ACE; the disease is breast neoplasm.